PSSD Current Views

So about a month ago I posted a few links on Reddit regarding PSSD, most of them related to glutamate mutant genes and some others. What I've found through my research is that above all, hormone sensitivity is reduced in PSSD; causing many to report that TRT and such would not affect them or benefit them much. Instead, supraphysiological levels of Test, DHT or sometimes Progesterone have done the trick.

The current views as in the rest of PSSD have not changed much, there is still most of the research surrounding SERT downregulation and 5-HT1A-desensitization; creating a functional excess of serotonin firing.

The rest of the hypothesis centers around hormone sensitivity and hypothalamic nerve activity.

Do you believe Hormone Sensitivity can eventually return to its original baseline?

And does this mean Anabolic Steroids and something like a Progesterone cream could prove helpful?

Very interesting.

Miguel29 wrote:Do you believe Hormone Sensitivity can eventually return to its original baseline?

And does this mean Anabolic Steroids and something like a Progesterone cream could prove helpful?

Very interesting.

I think the vast majority of PSSD patients would benefit from Progesterone antagonists not identical hormones, I was just stating it for statistical purposes. Its been documented. I think AAS (anabolic steroids) have a lot of risks that, in addition to being frequently misused, may not be a good long-term solution for PSSD sufferers.

If you could use anabolic steroids responsibly, it might be an option but unfortunately there is no way for me to guarantee that - and you would be taking your own risks.

I can't in good conscience simply say that is the way to go therefore. But I will say that if you were to go that route you might benefit (hypothetically) from something like Proviron which might block Progesterone a bit. Naps Gear has a good quality product for it.

https://www.napsgear.org/index.php?ref=2522