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Trazodone gave me PSSD

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51 Re: Trazodone gave me PSSD on Thu Jun 21, 2018 10:28 am

Trazohell


I'm back from the hospital.
The doctors could not find anything.
It has been done:
MRI of the head and lumbar spine
NCS hands and feet
Lumbar puncture
Ultrasound bladder / prostate / testes

Shilajit helps with libido, maybe adding something like yohimbine to lower serotonin even more?

52 Re: Trazodone gave me PSSD on Thu Jun 21, 2018 9:23 pm

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight
Trazohell wrote:I'm back from the hospital.
The doctors could not find anything.
It has been done:
MRI of the head and lumbar spine
NCS hands and feet
Lumbar puncture
Ultrasound bladder / prostate / testes

Shilajit helps with libido, maybe adding something like yohimbine to lower serotonin even more?
Yohimbine would be interesting from experimental point. Some helps, me harms. Not sure how it should lower serotonin, but its adrenergic action is interesting.

Consider supplements from my stack too (for longterm experiment).

53 Re: Trazodone gave me PSSD on Sun Jul 01, 2018 11:52 am

Trazohell


I have been taking St. John's wort again for a few days because the Shilaiat also made me somehow empty in my head and I'm tired of walking around like a zombie.
Also, I have now a stressful time before the start of education
(the company where I have completed the internship) and the move.
As I am no longer able to cope with chemistry after the experience, JHK seems to me the best alternative.
The feeling down there is actually better, the mood went up after only two tablets.
Libido is difficult to say, I think something improved too. The only thing that strikes me that sometimes it takes forever to orgasm, that is sometimes a bit annoying but not bad.
So it seems that my receptors are still reacting to substances and are not completely in the ass.
Also, serotonin does not seem to be bad at PSSD per se.
I even think by now that the main culprit is the loss of SERT, the serotonin transporter, which has been shown to downregulate the SSRI.
Although serotonin has a strong inhibitory effect on the sex drive, it is also necessary to a certain extent, as it is also involved in the control of sexuality.
In any case, JHK is able to upregulate the serotonin receptors 5HT1 / 5HT2 involved in PSSD and additionally releases important dopamine for sexuality, so I really recommend taking it 6-9 months as recommended on the instruction leaflet by the end of March 2019.
As long as nothing gets worse, it can only get better.
Sports and green tea help too.

54 Re: Trazodone gave me PSSD on Sun Jul 01, 2018 10:44 pm

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight
I only found jhk is somethink to help Kurdistan, lol.

It really could be that ssris reduce number of SERT binding sites over short time.
Other changes are mentioned like changes in serotonin synthesis, decrease in turnover (5-hiaa).
There are also receptors with high and low affinities.

Jay recently published a new article about kappa antagonists. I saw that study year ago but only now I noticed that sjw contains a mu antagonist. Also it seems green (best), oolong and black tea have a quantity of godd mu/kappa antagonist. Also caffeine is somewhat antagonistic to mu receptors.

55 Re: Trazodone gave me PSSD on Mon Sep 10, 2018 11:39 am

Trazohell


Hello, I thought I'll call after such a long time.
Faith contacted the PSSD forum and said that he was cured by pelvic floor training, which gives me a lot of hope.
I start training with a physiotherapist tomorrow. I also started Moclobemid, I think I feel a little bit clearer, but it's just the third day.

56 Re: Trazodone gave me PSSD on Mon Sep 10, 2018 9:16 pm

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight
Hi, I know that Cool

57 Re: Trazodone gave me PSSD on Sat Nov 03, 2018 11:50 am

Area-1255

Area-1255
Admin / Head Writer
Admin / Head Writer
Trazohell wrote:Hello, I thought I'll call after such a long time.
Faith contacted the PSSD forum and said that he was cured by pelvic floor training, which gives me a lot of hope.
I start training with a physiotherapist tomorrow. I also started Moclobemid, I think I feel a little bit clearer, but it's just the third day.

Hi Trazohell!
...Sorry for my long absence!
Do you feel any OTHER effects from the Moclobemide, yet?
Things like relief of Anhedonia, improvement in Energy, Mood, Senses or Musical Enjoyment???
It might be to early to tell.
But many people get "enhancement" of these types of things on Moclobemide.
See Article Below for more information!
--> https://area1255.blogspot.com/2017/01/antidepressants-that-increase-sex-drive.html

http://area-1255.forumotion.com

58 Re: Trazodone gave me PSSD on Sun Dec 23, 2018 12:58 pm

Trazohell


It's been a while since I was last active and I wanted to report back on my current status.
Unfortunately, I did not manage to heal until the end of the year, so my fight will continue in 2019.

However, I have made a modest progress with physiotherapy for the pelvic floor.
The penis root does not feel so hardened anymore, libido has been slightly elevated lately.
Maybe BPC-157 has done something to cure muscles and nerves, reduce excess serotonin, and modulate dopamine. It made me a little clearer and at the same time gave me a slight depersonalization.
I still have the problem, as soon as the testicles are no longer supported by my pants (by jamming the pants under the scrotum) something is disconnected and immediately the erection gets worse.
It definitely goes in the direction of the pelvic floor, but it would not explain why, for example, I do not react to alcohol like I used to.
It is to despair.

To your question with Moclobemid. It did not do anything great for me. I sometimes felt mentally a little better and then worse again, probably depending on which neurotransmitter outweighed.
I also tested Buprobion, but a single pill gave me terrible depersonalization.
It seems that DP is caused by low serotonin and elevated dopamine, and although it is not my main concern, I find this aspect interesting.
When I was in the Klinik because of the DP, my libido was overly high, but I had massive anxiety and sleep disturbances, so unfortunately I chose Trazodon. (I think today it was low serotonin and high dopamine).
I wish I had just taking nothing more.

But the mental status is also important for the healing, I can not deny that I am still depressed and can not distance myself from suicidal thoughts because of the problem. I'm thinking about trying Tianeptin or Selegelin. I read some anecdotal reports from people who say that it can reduce their anhedonia and increase libido.
I even read it from three people who have regained all their libido and feelings through Luvox.
Sometimes I think I should risk simply returning to Luvox where I know I tolerate it instead of experimenting with my body, hoping brain chemistry will switch back then. Low dose SSRI has also cured someone with hard flaccid, which is very similar to my problem. But I think after all to return to SSRI would be madness ...

I communicate a lot with a user named Zadig777, who also has similar problems after Trazodon. He suspects something has gone wrong with noradrenaline, since trazodone would prevent binding to its receptor.
What do you think to this?

59 Re: Trazodone gave me PSSD on Mon Jan 14, 2019 4:35 am

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight
Don't despair, we have some real connections now.

You may try yohimbine, since it's used in for urinary and ejaculatory symptoms. It's clearly mCPP action that blocks your muscles, probably due to spasm or something like that. It's on a spinal level.

Also use omega 3 please. It's of multiple importance in every neurologic disease.

60 Re: Trazodone gave me PSSD on Mon Jan 14, 2019 11:53 pm

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight
Effects of m-clorophenylpiperazine on penile and bladder function in rats
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.859.8572&rep=rep1&type=pdf
The effects of m-chlorophenylpiperazine (MCPP), a serotonin agonist, on spontaneous and evoked neural firing in nerves supplying the penis and bladder were examined in the urethan-anesthetized rat. MCPP (0.1-10 mg/kg iv) elicited, after a 2- to 4-min delay, an increase in spontaneous firing in cavernous nerves but no detectable firing in bladder nerves. The cavernous nerve firing was accompanied by an increase in intracavernous pressure and a depression of rhythmic bladder activity. Administration of ganglionic-blocking agents or transection of peripheral nerves revealed that the cavernous nerve discharge was mediated by activation of pre-ganglionic cholinergic pathways in the pelvic nerve. The effects of MCPP were noted in intact as well as in acute and chronic spinal rats and were prevented by the administration of the serotonin (5-HT) antagonist, metergoline (3 mg/kg im). These data indicate that pharmacological activation of 5-HT receptors, possibly of the 5-HT1B subtype, can facilitate the sacral preganglionic outflow to the penis and inhibit bladder activity.
cherry

61 Re: Trazodone gave me PSSD on Tue Jan 15, 2019 12:52 pm

Trazohell


Wow, so you think it might have been the Trazodone's McPP (which is serotonin agonist) metabolism? But why am I stuck in this state and how can it block muscle?
So you think Metergoline could reverse my condition?
I have something to consider because it blocks multiple serotonin receptors and trazodone also do this.

62 Re: Trazodone gave me PSSD on Wed Jan 16, 2019 1:21 am

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight
I think you can have some success with metergoline, yohimbine. I'm sure you will also have benefits with a DHA capsules supplement/flaxseed(+b12) like I did. New discovery of bethacholine/methacholine/urercholine on pssdforum could be promising because of spinal cholinergic neurons influence on contractility. Cayenne pepper may help. I think PQQ or cayenne pepper helped in DEC2017 to me. I described it to Cipro - in this period I regained to maybe 50-70 percent my ability to contract muscles and feel it during sleep, while earlier, although hard, morning erections were not detectable. It also helped greatly in not losing erections. However ability to ejaculate faster and sustain I attribute more to omega 3.

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