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Last edited by arkaeik on Thu Oct 31, 2019 3:26 pm; edited 2 times in total (Reason for editing : Deleted)
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Last edited by arkaeik on Thu Oct 31, 2019 3:26 pm; edited 2 times in total (Reason for editing : Deleted)
Last edited by arkaeik on Thu Oct 31, 2019 3:28 pm; edited 2 times in total (Reason for editing : Deleted)
arkaeik wrote:The high doses of T were definitely a bad idea. They've made my testicles shrink a lot and I've also realized that T is not the problem in PSSD. It's how the T is utilized.
I think I've pinpointed the root mechanism of most PSSD cases, maybe not the ones in females though. It's been demonstrated that sertraline (and presumably other SSRI's) can have epigenetic effects on steroidogenesis. This is most likely the case for finasteride too, which is less surprising given that it's known as a 5a reductase inhibitor. The symptoms of PSSD, PFS and PAS are identical to my knowledge so this indicates that the cause is the same.
In my opinion the root cause of these syndromes is altered gene expression regarding steroidogenesis. Only certain individuals are genetically predisposed and are unlucky enough to get this which is why the majority who take these drugs do not have permanent effects. Altered gene expression results in lower DHT and several other steroids. This will have a profound effect on the body.
The way I came to this conclusion was observing that my genitals became physically normal upon taking DHT (in the last post I said it was T, but I took them at the same time and I think it's the DHT). DHT is responsible for external genital development. My genitals are now back to PSSD state a few weeks after the DHT dose.
There is also a study that demonstrates that rats treated neonatally with clomipramine displayed sexual dysfunction. When given estradiol and DHT as adults, their sexual function was restored. The researchers explicitly mentioned that testosterone did not work. Also, the estradiol and DHT had to be taken at the same time or it would not work.
The key seems to be finding a way to reverse these epigenetic changes. Unfortunately I don't know of a reliable way to do that. If epigenetic changes are induced in the same direction as the effects of a drug then perhaps you could reverse the changes by taking the lacking substances (estradiol and DHT it seems).
Sources if interested:
https://academic.oup.com/toxsci/article/163/2/609/4947780
https://www.researchgate.net/publication/326657434_The_Post-finasteride_Syndrome_Clinical_Manifestation_of_Drug-Induced_Epigenetics_Due_to_Endocrine_Disruption
https://www.ncbi.nlm.nih.gov/pubmed/25449595
Area-1255 » Area-1255's Extensive Sexual Health Forum » PSSD Treatment Suggestions / Experiences » Would like some information about how physical sex drive works
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