ok, so Im struggling to understand something here.....people who have this due to taking antipsychotics....perticulraly complete anhedonia where they can fee NO emotions at all......this confuses me alot
for this reason....I can understand that desenstisation of 5ht1a somehow causes anhedonia...I dont think its a flooding of serotonin as surely then it would keep the serotonin receptors downregulated on the pre synaptic side, and that would yes stop anxiety etc as we do see in people, but I am for now ok with knowing that I wont understand that for now.....
But people who have the exact same symptom set from starting or stopping an antipsychotic, this I dont undersatdn...yes whilst ON the AP as iit has blocked dopamine, that makes sense, no problem there....but this can happen when people STOP taking an AP.......now receptors should have UPREGULATED in response to APs...we know this is true as we see things like TD developing.....so how can withdrawing from an AP cause sexual disfunction and anhedonia??
the only theory I have right now is that by constant blockade of dopamine autoreceptors, there has been upregulation......therefore perhaps upregulated dopamine autoreceptors are being activated at huge rates and therefore inhibiting dopamine release......but that would lead also so akathisia etc, unless its in a specific brain region??
Id be really interested to hear your veiws on this......
for this reason....I can understand that desenstisation of 5ht1a somehow causes anhedonia...I dont think its a flooding of serotonin as surely then it would keep the serotonin receptors downregulated on the pre synaptic side, and that would yes stop anxiety etc as we do see in people, but I am for now ok with knowing that I wont understand that for now.....
But people who have the exact same symptom set from starting or stopping an antipsychotic, this I dont undersatdn...yes whilst ON the AP as iit has blocked dopamine, that makes sense, no problem there....but this can happen when people STOP taking an AP.......now receptors should have UPREGULATED in response to APs...we know this is true as we see things like TD developing.....so how can withdrawing from an AP cause sexual disfunction and anhedonia??
the only theory I have right now is that by constant blockade of dopamine autoreceptors, there has been upregulation......therefore perhaps upregulated dopamine autoreceptors are being activated at huge rates and therefore inhibiting dopamine release......but that would lead also so akathisia etc, unless its in a specific brain region??
Id be really interested to hear your veiws on this......