I think I will have to quit. Berberine i read is very toxic to the liver . I have noticed My hands are a little bit bigger and my face has sligghtly changed.. I dont know if I am having a growth spurth or if its berberine... Im 20 years old . Someone said Berberine can change your DNA or something...
Well it doesent seem to be working anyway.. I mean I do feel different and better to be honest but my anxiety is definitely still there and I dont think it matters how long I take them...
Either I have sensitive serotonin receptors Or TOO many serotonin receptors.. No Idea... But it has To be Either of them !.... Thats why my only choice now is a serotonin receptor antagonist..
excluding: Cyproheptadine,Metergoline (<-- they didnt work ) and Antipsychotic Meds ( dont wanna block dopamine)
So its either Mianserin or Mirtazapine or if you know of any better alternatives..https://www.ncbi.nlm.nih.gov/pubmed/10876814
This study mentions 5-HT1A-receptor , 5-HT2 and 5-HT3 receptors have shown anxiolytic effects, possibly the 5-HT6 receptors too.https://www.ncbi.nlm.nih.gov/pubmed/24287720
Rapid anxiolytic effects of a 5-HT₄ receptor
So I dont know if its agonism or antagonism which produce the anxylotic effect on the receptors but what I do know ANTAGONISM on the 5ht2 receptors are good for anxiety I believe they are the most involved in anxiety learning etc.
So from what I can gather Mianserin/mirtazapine seems to be my best Option.. I have already tried all the other methods .
And it should WORK .. Zyprexa did... this 1 should too..
Mirtazapine + wellbutrin is a well known combo.
wellbutrin increases Norepinephrine well but not so much on dopamine to produce an effect.
But mianserin seems more potent than mirtazapine
based on the Pharmacology the Mianserin seems better .. It acts on more alpha receptors (increasing NE?) and Inhibits NET (also increasing NE?) and more potent blocks Serotonin receptors.
Correct me if I am wrong Im noob at this stuff.
So I Will try to go for Mianserin + Wellbutrin
and maybe in the future add an dopamine agonist like Abilify...
But yeah thats my plan..........
its been like 4 days since I started the 3 SERT activators
... Maybe I will give it a few more days IDK...
Maybe the sert activators since they have helped me calm down and reduce stress my body can start working again thus my growth spurth kicked in but couldnt before due to the stress?
or am I reaching lol.
But before I go the drug plan ... Is there anything else I should try? I know you probably want me to give the SERT activvators a little bit longer.... maybe 1 more week I dont know.
Do you know if there is anything else I can try when it comes to this serotonin stuff?