I thought CB1 was responsible for activating the NMDA system to surpress the amygdala during stress? I dont know anymore. I know that low cannabinoid system is linked to enlarged amygdala..
These findings show that anandamide and 2-AG divergently regulate the HPA axis response to stress: while habituation of the stress-induced HPA axis via 2-AG prevents excessive secretion of glucocorticoids to non-threatening stimuli, the increase of basal corticosterone secretion resulting from decreased anandamide allows for a facilitated response of the HPA axis to novel stimuli.
so i can conclude anandamide and 2-ag decrease stress in the amygdala? And supposedly Marijuana contains a lot of cannabinoids that can increase the cannabinoid system cb1 ,cb2 and Im assuming anandamide and 2-ag too?
I did read https://www.selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/
but all the methods seem relativity weak and I dont think wont make a big difference.
On another forum some guy suggested for me to take a low dose THC preparation , thc is what I think increases just cb1. But the thing is I want full cannabinoid system support ( anandamide etc) . I think I will have to just take Marijuana . But I will have to watch out for CBD because I think that blocks CB1.
according to this
The T allele may cause lower CB1 receptor numbers and less CB1 activation . The T allele of rs1049353 may cause lower receptor numbers and less activation. With this variation, the receptors also don't become significantly less sensitive when activated (R) - i.e. you don't build up tolerance
it says my problem is only CB1 receptors.... I dont know how all the cannabinoid receptors/stuff related to the system are connected. But so THC should do then... Does increasing cb1 increase faah/anandamide etc?
I wonder if Marijuana has an effect on the whole cannabinoid system or just cb1/cb2. Also does marijuana just touch the cannabinoid system nothing else?
here are my other 2 cannabinoid genes that were marked as red flag on Selfdecode:
description( Contains Risk Alleles)https://www.selfdecode.com/gene/crhr1/
desc(Contains Risk Alleles / Potentially bad gene)https://www.selfdecode.com/gene/cnr1/
and ofc this 1 that i been talkin bout the most https://www.selfdecode.com/snp/rs1049353/
SO I have 3 different mutations (bad low) in my cannabinoid system?