Trazodone gave me PSSD

I'm back from the hospital.
The doctors could not find anything.
It has been done:
MRI of the head and lumbar spine
NCS hands and feet
Lumbar puncture
Ultrasound bladder / prostate / testes

Shilajit helps with libido, maybe adding something like yohimbine to lower serotonin even more?

Trazohell wrote:I'm back from the hospital.
The doctors could not find anything.
It has been done:
MRI of the head and lumbar spine
NCS hands and feet
Lumbar puncture
Ultrasound bladder / prostate / testes

Shilajit helps with libido, maybe adding something like yohimbine to lower serotonin even more?

Yohimbine would be interesting from experimental point. Some helps, me harms. Not sure how it should lower serotonin, but its adrenergic action is interesting.

Consider supplements from my stack too (for longterm experiment).

I have been taking St. John's wort again for a few days because the Shilaiat also made me somehow empty in my head and I'm tired of walking around like a zombie.
Also, I have now a stressful time before the start of education
(the company where I have completed the internship) and the move.
As I am no longer able to cope with chemistry after the experience, JHK seems to me the best alternative.
The feeling down there is actually better, the mood went up after only two tablets.
Libido is difficult to say, I think something improved too. The only thing that strikes me that sometimes it takes forever to orgasm, that is sometimes a bit annoying but not bad.
So it seems that my receptors are still reacting to substances and are not completely in the ass.
Also, serotonin does not seem to be bad at PSSD per se.
I even think by now that the main culprit is the loss of SERT, the serotonin transporter, which has been shown to downregulate the SSRI.
Although serotonin has a strong inhibitory effect on the sex drive, it is also necessary to a certain extent, as it is also involved in the control of sexuality.
In any case, JHK is able to upregulate the serotonin receptors 5HT1 / 5HT2 involved in PSSD and additionally releases important dopamine for sexuality, so I really recommend taking it 6-9 months as recommended on the instruction leaflet by the end of March 2019.
As long as nothing gets worse, it can only get better.
Sports and green tea help too.

I only found jhk is somethink to help Kurdistan, lol.

It really could be that ssris reduce number of SERT binding sites over short time.
Other changes are mentioned like changes in serotonin synthesis, decrease in turnover (5-hiaa).
There are also receptors with high and low affinities.

Jay recently published a new article about kappa antagonists. I saw that study year ago but only now I noticed that sjw contains a mu antagonist. Also it seems green (best), oolong and black tea have a quantity of godd mu/kappa antagonist. Also caffeine is somewhat antagonistic to mu receptors.

Hello, I thought I'll call after such a long time.
Faith contacted the PSSD forum and said that he was cured by pelvic floor training, which gives me a lot of hope.
I start training with a physiotherapist tomorrow. I also started Moclobemid, I think I feel a little bit clearer, but it's just the third day.

Hi, I know that

Trazohell wrote:Hello, I thought I'll call after such a long time.
Faith contacted the PSSD forum and said that he was cured by pelvic floor training, which gives me a lot of hope.
I start training with a physiotherapist tomorrow. I also started Moclobemid, I think I feel a little bit clearer, but it's just the third day.

Hi Trazohell!
...Sorry for my long absence!
Do you feel any OTHER effects from the Moclobemide, yet?
Things like relief of Anhedonia, improvement in Energy, Mood, Senses or Musical Enjoyment???
It might be to early to tell.
But many people get "enhancement" of these types of things on Moclobemide.
See Article Below for more information!
--> https://area1255.blogspot.com/2017/01/antidepressants-that-increase-sex-drive.html

It's been a while since I was last active and I wanted to report back on my current status.
Unfortunately, I did not manage to heal until the end of the year, so my fight will continue in 2019.

However, I have made a modest progress with physiotherapy for the pelvic floor.
The penis root does not feel so hardened anymore, libido has been slightly elevated lately.
Maybe BPC-157 has done something to cure muscles and nerves, reduce excess serotonin, and modulate dopamine. It made me a little clearer and at the same time gave me a slight depersonalization.
I still have the problem, as soon as the testicles are no longer supported by my pants (by jamming the pants under the scrotum) something is disconnected and immediately the erection gets worse.
It definitely goes in the direction of the pelvic floor, but it would not explain why, for example, I do not react to alcohol like I used to.
It is to despair.

To your question with Moclobemid. It did not do anything great for me. I sometimes felt mentally a little better and then worse again, probably depending on which neurotransmitter outweighed.
I also tested Buprobion, but a single pill gave me terrible depersonalization.
It seems that DP is caused by low serotonin and elevated dopamine, and although it is not my main concern, I find this aspect interesting.
When I was in the Klinik because of the DP, my libido was overly high, but I had massive anxiety and sleep disturbances, so unfortunately I chose Trazodon. (I think today it was low serotonin and high dopamine).
I wish I had just taking nothing more.

But the mental status is also important for the healing, I can not deny that I am still depressed and can not distance myself from suicidal thoughts because of the problem. I'm thinking about trying Tianeptin or Selegelin. I read some anecdotal reports from people who say that it can reduce their anhedonia and increase libido.
I even read it from three people who have regained all their libido and feelings through Luvox.
Sometimes I think I should risk simply returning to Luvox where I know I tolerate it instead of experimenting with my body, hoping brain chemistry will switch back then. Low dose SSRI has also cured someone with hard flaccid, which is very similar to my problem. But I think after all to return to SSRI would be madness ...

I communicate a lot with a user named Zadig777, who also has similar problems after Trazodon. He suspects something has gone wrong with noradrenaline, since trazodone would prevent binding to its receptor.
What do you think to this?

Don't despair, we have some real connections now.

You may try yohimbine, since it's used in for urinary and ejaculatory symptoms. It's clearly mCPP action that blocks your muscles, probably due to spasm or something like that. It's on a spinal level.

Also use omega 3 please. It's of multiple importance in every neurologic disease.

Effects of m-clorophenylpiperazine on penile and bladder function in rats
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.859.8572&rep=rep1&type=pdf
The effects of m-chlorophenylpiperazine (MCPP), a serotonin agonist, on spontaneous and evoked neural firing in nerves supplying the penis and bladder were examined in the urethan-anesthetized rat. MCPP (0.1-10 mg/kg iv) elicited, after a 2- to 4-min delay, an increase in spontaneous firing in cavernous nerves but no detectable firing in bladder nerves. The cavernous nerve firing was accompanied by an increase in intracavernous pressure and a depression of rhythmic bladder activity. Administration of ganglionic-blocking agents or transection of peripheral nerves revealed that the cavernous nerve discharge was mediated by activation of pre-ganglionic cholinergic pathways in the pelvic nerve. The effects of MCPP were noted in intact as well as in acute and chronic spinal rats and were prevented by the administration of the serotonin (5-HT) antagonist, metergoline (3 mg/kg im). These data indicate that pharmacological activation of 5-HT receptors, possibly of the 5-HT1B subtype, can facilitate the sacral preganglionic outflow to the penis and inhibit bladder activity.

Wow, so you think it might have been the Trazodone's McPP (which is serotonin agonist) metabolism? But why am I stuck in this state and how can it block muscle?
So you think Metergoline could reverse my condition?
I have something to consider because it blocks multiple serotonin receptors and trazodone also do this.

I think you can have some success with metergoline, yohimbine. I'm sure you will also have benefits with a DHA capsules supplement/flaxseed(+b12) like I did. New discovery of bethacholine/methacholine/urercholine on pssdforum could be promising because of spinal cholinergic neurons influence on contractility. Cayenne pepper may help. I think PQQ or cayenne pepper helped in DEC2017 to me. I described it to Cipro - in this period I regained to maybe 50-70 percent my ability to contract muscles and feel it during sleep, while earlier, although hard, morning erections were not detectable. It also helped greatly in not losing erections. However ability to ejaculate faster and sustain I attribute more to omega 3.

Hello Area Forum,

I would like to return with some important research, even if nothing was found.
MRI from the pelvic floor was unremarkable.
See here a picture of an extensive hormone test that I have had carried out (please klick to see more):




What strikes me is that, unlike the last time, testosterone has dropped slightly while estrogen is elevated.
Zadig777 has already tried out Metergoline and a dopamine agonist and it has done nothing for him.
He wants to take Alpha Blocker with Cialis next, but I'm afraid to make it worse because Trazodon is an ALphablocker.
Maybe I have a nerve damage in the pelvic floor, because my vessels were healthy and Trazodone has made them too far.
And even it would help with erections and pelvic pain, I also do not know how it affects my other problems like no reaction to alcohol, non-existent libido and generally demand for human proximity.
It definitely speaks for changes in brain chemistry, probably oxytocin and dopamine downregulation via 5HT1/5HT2 pathway.
I absolutely do not know what to do anymore.

I also tried Urocholine or Myocholine, it does not do anything like the other things I've tried out.
The only things that have helped me really so far have been physiotherapy for the pelvic floor for pain relief and BCP-157 for relieving anhedonia.
But as soon as I masturbate, the pain comes back. My work with many stooping and climbing obstacles also triggers it.
I seriously consider taking a SSRI+TCA combination, maybe Luvox with Nortryptiline. A few guys from Longeciity.org get back euphoria, reaction to stimulants and libido with it. Look for example here:

https://www.longecity.org/forum/topic/85411-the-causes-of-depression/

My life is just a nightmare, it could have been so great without this shit.



Zadig's combo theoretically delays ejaculation, reduces sensitivity and may worsen semen expulsion. You suspect right.
I read that tryciclics or duloxetine are used for incontinence and named anticholinergics, all ssri are anticholinergics at least via 5ht1b, I read the study you posted long time ago and found it interesting then. Ginkgo biloba/berberine acts on M2 muscarinic receptors by the way. I you have /or had heart rate issues, arrhythmia, vision blurring, loss of intense sweating, gastrointestinal issues, breathin changes then you should continue bethanechol for some time. Or may be you skin feeling on scratching changed to burning instead of euphoria like in me was?

Zadig's combo theoretically delays ejaculation, reduces sensitivity and may worsen semen expulsion. You suspect right.
I read that tryciclics or duloxetine are used for incontinence and named anticholinergics, all ssri are anticholinergics at least via 5ht1b, I read the study you posted long time ago and found it interesting then. Ginkgo biloba/berberine acts on M2 muscarinic receptors by the way. I you have /or had heart rate issues, arrhythmia, vision blurring, loss of intense sweating, gastrointestinal issues, breathin changes then you should continue bethanechol for some time. Or may be you skin feeling on scratching changed to burning instead of euphoria like in me was?

SORRY PUSHED THE WRONG BUTTON)

Ciprofloxacin recently published his readings. He also has low fT4, very high estradiol and low cortisol. Look. You have high DHT. Also low ferritin, and that could be important, should be 70-100, I think. FSH is low as in many with pssd. That is what I see immediately.

Low Eisen

TFS is transferrin saturation. Problems in Iron on 3 tests.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754511/
Low hematokrit.

May be visit gastroenterologist?

Read drama on pssdforum, thought about this

Reduced cortisol secretion in patients with iron deficiency.
The iron-containing protein cytochrome P-450 is present in high concentration in the adrenal cortex and is involved in the synthesis of corticosterone. This study was designed to determine the cortisol response to adrenocorticotropin (ACTH) in patients with severe iron deficiency. Eleven patients with iron deficiency and 15 normal controls were studied. Fasting blood samples were taken from all the subjects before and 30, 60 and 120 min after infusion of 25 units of ACTH for plasma cortisol determination. Six patients had blood samples collected at night, too. The same test was performed in 6 patients with iron deficiency, 7 days after therapy with 800 mg of ferrous sulfate. No significant differences were observed between patients and controls for the baseline cortisol values. The cortisol secretion and the increment at 30, 60 and 120 min after ACTH infusion were significantly lower in patients than in controls, either before or after ferrous sulfate therapy. There were no significant differences between baseline and stimulated cortisol values in patients before and after 7 days of ferrous sulfate therapy. There was no change in cortisol secretion rhythm in patients with iron deficiency (cortisol level at night = 5.1 +/- 4.3 micrograms/dl). In conclusion, the results of the present study showed that, in patients with severe iron deficiency, the cortisol secretion after ACTH stimulation was decreased.

link

Hello Trazohell, did you find any solution to your problem? i have similar problems to yours after taking trazodone. Can you please get in touch with me somehow?