A lot of unpleasant things have happened but they are helping me more and more to better identify the problem.
I used methylated methylated vitamin B12 for about two months together with a hypothetical low methylation. (NOTE I HAVE NOT TAKEN INTO CONSIDERATION THE HIGH ISTAMINE AND DISORDERS TO THE MASTOCITES).
The first month I had great benefits and feedback both on the psychological and on the physical level. It really seemed that I had found the problem.
The second month however I had a cascade of negative symptoms due to a partial block of methylation and a B12-induced potassium deficiency (You can find more details in the Phoenix Rising CFS Forum, really a bible regarding methylation and fatigue problems chronic).
I decided to block all the supplements for a week. I read that a sub-methylator would benefit from calcium, magnesium, zinc, SAM-e, B2 and B6, VIT. C, inositol and methionine but not Folate and B12.
Folate, choline, copper and histidine could make the situation worse.
Reading on the web the characteristics of a sub-methylator I see that it should have a high histamine resulting in low SAM-e and SAH and low neurotransmitter activity.
Based on this theory I decided to limit as far as possible the foods rich in histamine and those that release it. I also decide to limit foods with many lecithins as there would be less mast cell activation and histamine release.
How do you see this thing? food histamine is decomposed by DAO while internal body histamine is managed by HMNT.
I believe that my chronic post-exertion symptoms and those in mental efforts are highly dependent on a mast cell disorder that causes a too fluctuating histamine. In any case when mast cells are released in my case, they are continually damaged. The symptoms of autism when there is no degradation are practically absent and I love life, I go out, I increase the desire to explore, talk and make knowledge.
Last night I tried to take a second generation H1 antihistamine that I had at home and the effects were very positive especially for sleeping because I have never slept so 'well and well in my life (histamine regulates the rhythms of sleep over that those of the addict with leptin and ghrelin).
When I have an imbalance or breakage of the mast cells I suddenly have a terrible hunger from binge eating ... more labored breathing, change of mood, voice, less motivation etc.
How do you recommend continuing my journey? Thank you all