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151My History - Page 7 Empty Re: My History Sun Sep 01, 2019 9:11 am

phenyl90



I don't know what to do and what to try ... they are 15 years without improvements Does it make sense to limit tryptophan to kyurenic acid?

153My History - Page 7 Empty Re: My History Tue Sep 03, 2019 11:33 am

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight

oxytocin spray
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458113/
oleanolic acid
https://www.ncbi.nlm.nih.gov/pubmed/24997455

interestingly baclofen is associated with psychosis although many claim its strong effects on anxiety and it may strongly delay ejaculation.

can magnolia officinalis help?
https://www.ncbi.nlm.nih.gov/pubmed/21301322

muscarinic agonist
https://www.ncbi.nlm.nih.gov/pubmed/18651995

154My History - Page 7 Empty Re: My History Wed Sep 04, 2019 12:19 am

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight

Found interesting recent experiment showing a way how NMDA can be blocked via kynurenic acid overproduction

Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice.
https://www.ncbi.nlm.nih.gov/pubmed/31391545
Accumulating evidence suggests that gut microbiota plays a role in the pathogenesis of schizophrenia via the microbiota-gut-brain axis. This study sought to investigate whether transplantation of fecal microbiota from drug-free patients with schizophrenia into specific pathogen-free mice could cause schizophrenia-like behavioral abnormalities. The results revealed that transplantation of fecal microbiota from schizophrenic patients into antibiotic-treated mice caused behavioral abnormalities such as psychomotor hyperactivity, impaired learning and memory in the recipient animals. These mice also showed elevation of the kynurenine-kynurenic acid pathway of tryptophan degradation in both periphery and brain, as well as increased basal extracellular dopamine in prefrontal cortex and 5-hydroxytryptamine in hippocampus, compared with their counterparts receiving feces from healthy controls. Furthermore, colonic luminal filtrates from the mice transplanted with patients' fecal microbiota increased both kynurenic acid synthesis and kynurenine aminotransferase II activity in cultured hepatocytes and forebrain cortical slices. Sixty species of donor-derived bacteria showed significant difference between the mice colonized with the patients' and the controls' fecal microbiota, highlighting 78 differentially enriched functional modules including tryptophan biosynthesis function. In conclusion, our study suggests that the abnormalities in the composition of gut microbiota contribute to the pathogenesis of schizophrenia partially through the manipulation of tryptophan-kynurenine metabolism.

155My History - Page 7 Empty Re: My History Thu Sep 05, 2019 11:44 am

phenyl90



Thanks for the studio links, as soon as I am on the desktop I will watch them.  What I can tell you is that in MY case the genes are the cause ... at least seeing my father.

Serine 2-3g a day is helping me a lot with some negative symptoms but unfortunately when it comes to a minimum commitment the anticipatory anxiety rises and when psychosis is in that place.

I don't think it's absolutely smart to BLOCK NMDA ... but open more channels.

B1 also helps 100 mg a day.
Unfortunately the disease is multifactorial and unpredictable.

I think the hypothesis of little circulating glutamate makes sense and it is right to act positively modulating NMDA.

Is it possible to do something about the genes second you?

DAAO, NRG1, DISC1, LMBRD1, COMT, DTMBP1, RSG4, PTK2B

I can also say that all the other supplements have failed ... including the NAC a few times has increased psychosis and flat affect.

Magnolia help but lower a lot adrenaline !!! Very bad but probably good for GABA and glutamate.

What can I do to delay ejaculation and excitement? antagonist 5-HT2C?

156My History - Page 7 Empty Re: My History Fri Sep 06, 2019 2:47 am

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight

ht2c/ht1b agonism delays ejaculation and lowers dopamine (these receptors can be anxiogenic), ht1b lowers glutamate and acetylcholine
, ht1a presynaptic facilitates ejaculation and it's anxiolytic.
https://link.springer.com/article/10.1007/s00221-019-05611-1

Why lowering adrenaline is bad for you if you have tension in interaction?
I read something about DISC1 but these genes are no familiar to me. I put a lot attention in closing 'holes' made by oxidative stress. As I put above, problems with gut can easily create inflammation, and actually even lower glutamate.

157My History - Page 7 Empty Re: My History Sun Sep 08, 2019 1:03 am

phenyl90



Thanks ! What Is agonist for this Two agonist receptor ?

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