Reducing allopregnanolone

Hello there. I probably have a high level of allopregnanolone. I want help here because people in Pssd Forum don't seem to be interested in it. I've read a lot of articles and I'm sure that's true. There are two types of people, people who have increased anxiety after pssd or pfs(low inhibitory neurosteroid levels), or people who have lost their anxiety(high inhibitory neurosteroid levels). From the first group of people, I read the writings of those who treated themselves with a low dose of ssri. Since SSRI increases the level of allopregnanolone, I think it would be useful to try most of those who have pfs and pssd. In my case, I have all of the signs of High GABA levels. If I ignore the fact that I've lost all my emotions, the most annoying thing about me is the brain fog. I want to permanently reduce the activity of my 3a-hsd enzyme to block excess allopregnanolone production. I couldn't find an active ingredient on the Internet. Medroxyprogesterone acetate may cause other problems and I am afraid to try. Are there any other drugs I can try? My only hope is the GAMSAs that temporarily work? Maybe I should give ssri to my body intermittently to produce less allopregnanolone?
My age is 15 also, I wouldn’t want to distract any other thing.

https://www.sciencedirect.com/science/article/pii/S0960076015301217
(Unfortunately, I couldn’t even order and try one of them in my country.)

Ciprofloxacin wrote:Hello there. I probably have a high level of allopregnanolone. I want help here because people in Pssd Forum don't seem to be interested in it. I've read a lot of articles and I'm sure that's true. There are two types of people, people who have increased anxiety after pssd or pfs(low inhibitory neurosteroid levels), or people who have lost their anxiety(high inhibitory neurosteroid levels). From the first group of people, I read the writings of those who treated themselves with a low dose of ssri. Since SSRI increases the level of allopregnanolone, I think it would be useful to try most of those who have pfs and pssd. In my case, I have all of the signs of High GABA levels. If I ignore the fact that I've lost all my emotions, the most annoying thing about me is the brain fog. I want to permanently reduce the activity of my 3a-hsd enzyme to block excess allopregnanolone production. I couldn't find an active ingredient on the Internet. Medroxyprogesterone acetate may cause other problems and I am afraid to try. Are there any other drugs I can try? My only hope is the GAMSAs that temporarily work? Maybe I should give ssri to my body intermittently to produce less allopregnanolone?
My age is 15 also, I wouldn’t want to distract any other thing.

https://www.sciencedirect.com/science/article/pii/S0960076015301217
(Unfortunately, I couldn’t even order and try one of them in my country.)

Hello, I read your discussion, and now think your idea on a disbalanced allopregnanolone/progesterone ratio is worth researching (also because I'm not very much interested in allopregnanolone since it seems not to fit anything except sexual receiptivity from what I remembered). I have these links on 3a-hsd negative regulation.
https://www.ncbi.nlm.nih.gov/pubmed/3200111
https://www.ncbi.nlm.nih.gov/pubmed/6093971
https://www.ncbi.nlm.nih.gov/pubmed/8477499
https://www.ncbi.nlm.nih.gov/pubmed/15894034
https://www.ncbi.nlm.nih.gov/pubmed/15219653
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840773/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290723/
https://www.ncbi.nlm.nih.gov/pubmed/12646198
https://www.ncbi.nlm.nih.gov/pubmed/27217114

So you see natural estrogenic modulators (like from red clover) also may regulate 3a-hsd. Paeonia may have another mechanism.
You tried indomethacin. But I think aspirin (which was found to improve lithium ED) is safer. But I would choose a concentrated willow (water extract) with higher salicin content if you have access to anything except Salix Alba (for a month). It may improve cognition|laziness actually (at least for exercise).

Thanks. Some of the studies above are interesting. I have learned that may the problem is not excess production of allo, but low 3a-HSD oxidation(reverse) activity. Did you notice that isotretinoine potently blocks oxidation activity of 3a-hsd? It’s one of the meds that cause pssd or pfs.

Do you may know a substance to increase oxidation activity of this enzyme?

PQQ
https://www.ncbi.nlm.nih.gov/pubmed/15915445
interestingly:
https://www.ncbi.nlm.nih.gov/pubmed/8824828
I tried this stuff in Dec-Jan (2 bottles).
Got great mood, maybe some arousal improvement but maybe not from this.
If you have access to iherb of course

Ciprofloxacin wrote:Thanks. Some of the studies above are interesting. I have learned that may the problem is not excess production of allo, but low 3a-HSD oxidation(reverse) activity. Did you notice that isotretinoine potently blocks oxidation activity of 3a-hsd? It’s one of the meds that cause pssd or pfs.

Do you may know a substance to increase oxidation activity of this enzyme?

Thank you for that you try to think out of box.
Accutane is full of shit, it stays in the body ~20 times longer than ATRA and lowers hormones like mead.

I have just tried the Saw Palmetto for the last 6 days (solgar). I can’t say what the hell did it make to me because I can’t properly observe myself. But I want to tell somethings about it.

- It elevated the cloud on the my brain a bit, I guess. I have tried again to read a book that I had been trying to read, and I found it bit easier to read. But sometimes, my mind was generally more foggy.
- My muscle coordination problem was bit better. But sometimes worse.
- My libido was better at second day, until I took the second dosage. My libido is worse now and my semen is way more watery.
- At First 10 hours I’m being generally worse after I took the dose, according to my observings.
Another reason that I cut off is that I noticed pain on my breasts. Unfortunately, I guess I caused the further depletion of DHT. Damn, Is it Gynecomastia?
I looked up on that links. I couldn’t find a proper(I couldn’t find paeonia extract, pqq and others. Except nicotine, but I don’t want to use it) substance to use. The coumestrol is found in some of the plants but they are mostly estrogenic ,I guess. While I’m not sure a bit about anything, I was have one evidence only that I have all the symptoms of excess GABA. And that’s opposite of most of the pfs and pssd community because they are way more anxious now.

The common problems seem like low dht. But how indomethacine decreases cognitive performance? it must increase dht with inhibiting 3a-hsd?

Ciprofloxacin wrote:I have just tried the Saw Palmetto for the last 6 days (solgar). I can’t say what the hell did it make to me because I can’t properly observe myself. But I want to tell somethings about it.

- It elevated the cloud on the my brain a bit, I guess. I have tried again to read a book that I had been trying to read, and I found it bit easier to read.  But sometimes, my mind was generally more foggy.
- My muscle coordination problem was bit better. But sometimes worse.
- My libido was better at second day, until I took the second dosage. My libido is worse now and my semen is way more watery.
- At First 10 hours I’m being generally worse after I took the dose, according to my observings.
Another reason that I cut off is that I noticed pain on my breasts.  Unfortunately, I guess  I caused the further depletion of DHT. Damn, Is it Gynecomastia?
   I looked up on that links. I couldn’t find a proper(I couldn’t find paeonia extract, pqq and others. Except nicotine, but I don’t want to use it) substance to use. The coumestrol is found in some of the plants but they are mostly estrogenic ,I guess. While I’m not sure a bit about anything, I was have one evidence only that I have all the symptoms of excess GABA. And that’s opposite of most of the pfs and pssd community because they are way more anxious now.

The common problems seem like low dht. But how indomethacine decreases cognitive performance? it must increase dht with inhibiting 3a-hsd?

There was no need for you to try saw palmetto. By the way when I tried vitex in the summer 2015, I had some 'breast' feeling, lol. So I think it's a sign of a progesterone peak. No need to try coumestrol or such, that was just for example. ANd of course no nicotine. PQQ you can get on iHERB, I mentioned it because it touches important nerve growth factor which increases rdh16. This may relieve some problems (mental and sensation). To increase cognition there are many things.
I know nothing about indomethacin itself and why it could worsen thinking but we definitely have oxidative stress which is the real reason to worsen cognition and memory, cox-2 pathway and its pge2 are upregulated for sure.
White willow can downregulate cox-2 and upregulate cox-1.
Also try milk thistle, it was shown to reduce ocd, it's notable itself, also https://www.ncbi.nlm.nih.gov/pubmed/19857526
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743846/
https://www.ncbi.nlm.nih.gov/pubmed/25712657

Also reductase will be affected
https://www.ncbi.nlm.nih.gov/pubmed/15249139
Nerve growth factor induces elevation of steroid 5alpha-reductase mRNA levels in rat C6 glioma cells through expression of transcription factor Egr-1

I have looked up to PQQ. It seems it could be helpful but unfortunately, I couldn’t find it on my country. And I guess, milk thistle is not a very good choice.

https://forum.propeciahelp.com/t/warning-milk-thistle-can-cause-persistent-side-effects/4382


I may have used more than one things lately. I took a 25 mg sertraline tablet once on monday evening. I couldn’t sleep on tuesday. Now, It’s been nearly 1 week since I cut off saw palmetto(solgar). Hairfall stopped nearly completely but I feel very weak. Cognitively, I may be tiny bit of better, since allopregnanolone is downregulated in pfs cases. But I’m worrying now because it’s worse to have too low DHT in my body. I don’t want to have a gynecomastia.

Ciprofloxacin wrote:I have looked up to PQQ. It seems it could be helpful but unfortunately, I couldn’t find it on my country. And I guess, milk thistle is not a very good choice.

https://forum.propeciahelp.com/t/warning-milk-thistle-can-cause-persistent-side-effects/4382


I may have used more than one things lately. I took a 25 mg sertraline tablet once on monday evening. I couldn’t sleep on tuesday. Now, It’s been nearly 1 week since I cut off saw palmetto(solgar). Hairfall stopped nearly completely but I feel very weak. Cognitively, I may be tiny bit of better, since allopregnanolone is downregulated in pfs cases. But I’m worrying now because it’s worse to have too low DHT in my body. I don’t want to have a gynecomastia.

Well
http://www.peaktestosterone.com/forum/index.php?topic=13103.0

But I'm talking about general health, and it's a notable herb for it.

If you can get tribulus you can try it.
Update: f*ck..
https://www.ncbi.nlm.nih.gov/pubmed/15454201
But I meant androgen receptors.
You may try a carnitine it must be available in your country I think. PQQ can be get mostly in U.S. I think but sometimes local markets can have it.

I can find carnitine, yes. Maybe it's the safest way but I can't be sure since I'm 16 yet.

I have noticed another symptome a few minutes ago.

I can't erect at all now. I was have mild ED before Saw palmetto but now it's more than 2 fold.
Also genital numbness is an another symptom.

I'm really sad.


It would be bit stubbornish but do you think that I can improve myself in all symptoms in once with balancing 3a-hsd? It may reduce allopregnanolone while increasing DHT. But I couldn't see any proper thing. PQQ not touching that enzyme, right?

Ciprofloxacin wrote:I can find carnitine, yes. Maybe it's the safest way but I can't be sure since I'm 16 yet.

I have noticed another symptome a few minutes ago.

I can't erect at all now. I was have mild ED before Saw palmetto but now it's more than 2 fold.
Also genital numbness is an another symptom.

I'm really sad.


It would be bit stubbornish but do you think that I can improve myself in all symptoms in once with balancing 3a-hsd? It may reduce allopregnanolone while increasing DHT. But I couldn't see any proper thing. PQQ not touching that enzyme, right?

According to research above PQQ may potently induce NGF. Since NGF was recently shown to significantly increase RDH16 (RODH4 which was shown to be reduced by fluoxetine) it is possible that 3-alpha-hsd reductive action will be balanced with oxidative (back to 5alpha-progesterone). Also research above gives hope to increase 5-alpha-reductase, so in sum we get less progesterone, less allopregnanolone, more DHT. But more important is that there are direct  studies showing mental improvements with PQQ and role of NGF in ED and much more I think.
https://www.ncbi.nlm.nih.gov/pubmed/29285284
https://www.ncbi.nlm.nih.gov/pubmed/29724155
https://www.ncbi.nlm.nih.gov/pubmed/24552354
https://www.ncbi.nlm.nih.gov/pubmed/16281507

Thanks! It seems it could be helpfull in all aspects. In my country it’s impossible to buy a med from abroad but I can add some foods containing it if it will be helpfull. Or it would be better if there is any other way to take pqq.

Have you had pssd too?


I have also found that but I don’t know how much possible to synthesis these substances or wether are they safe or not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1133240/

Yes, I had all typical symptoms of pssd, pleasure|immediate arousal and reproductive problems remain.

I could’t find any source for pqq in my country.

I was trying turmeric, black cumin seed oil, aspirin and black pepper as anti inflammatuar substances. They didn’t do anything to be honest. My brain probably melted because I have became a person who struggles to find the names of what he looking. It’s hard to say but they are too much for a 16 yo boy. I went to psychologist for about it but no luck. I want to get a hormone test but either, with no luck too. Do you have any last suggestion?
Sorry for grammar btw. I could’t check this with g. Translate.

Ciprofloxacin wrote:I could’t find any source for pqq in my country.

I was trying turmeric, black cumin seed oil, aspirin and black pepper as anti inflammatuar substances. They didn’t do anything to be honest. My brain probably melted because I have became a person who struggles to find the names of what he looking. It’s hard to say but they are too much for a 16 yo boy. I went to psychologist for about it but no luck. I want to get a hormone test but either, with no luck too. Do you have any last suggestion?
Sorry for grammar btw. I could’t check this with g. Translate.

yes, look here
https://area-1255.forumotion.com/t159p25-trazodone-gave-me-pssd#1392
btw someone deleted the last link, lol, but you'll find
black cumin is not bad at all, you should remember that these therapies could work in a month or in a week, some of them have accumulative effect, studies show protein change in a three month periold of regular intake
and your thought about tnf-alpha increased are correct, I'm sure
btw, read the long 2011 ED review by Andersson on pubmed, you'll understand a lot

kpavel wrote:

Ciprofloxacin wrote:I could’t find any source for pqq in my country.

I was trying turmeric, black cumin seed oil, aspirin and black pepper as anti inflammatuar substances. They didn’t do anything to be honest. My brain probably melted because I have became a person who struggles to find the names of what he looking. It’s hard to say but they are too much for a 16 yo boy. I went to psychologist for about it but no luck. I want to get a hormone test but either, with no luck too. Do you have any last suggestion?
Sorry for grammar btw. I could’t check this with g. Translate.

yes, look here
https://area-1255.forumotion.com/t159p25-trazodone-gave-me-pssd#1392
btw someone deleted the last link, lol, but you'll find
black cumin is not bad at all, you should remember that these therapies could work in a month or in a week, some of them have accumulative effect, studies show protein change in  a three month periold of regular intake
and your thought about tnf-alpha increased are correct, I'm sure
btw, read the long 2011 ED review by Andersson on pubmed, you'll understand a lot

I have read.

Curcumin has some weird coffe-like energy boosting effects. But it generally makes me worse. So I stopped to take it. I'm continuing with 2 teaspoon of black cumin seed oil and 1 teaspoon of cinnamon ceyloan.

Nothing worked yet tbh. All the symptoms are still worsening. I think, masturbation has a big role in this. This makes me that my problem could be hormonal. Breast and armpit pain, belly, pain in joints are also.

But, do I have a chance to fix if I make a test in a private hospital and show results to a doctor? Or, you know, biology is a complex thing, could be the other parts of this system affected from disturbtions? like hormone receptors.

Yes sure, they are affected. To fix pain buy a dark bottle of fresh linseed oil, store it closed and in refrigerator, either drink about 20-50 ml from it or take this amount in a salad with fruit and  spices. That will remove pain. Don't consume much of other fats like lard especially. Do that for at least 2 weeks. (about 0.5L)

Also make estrogen and progesterone measures.

I will definitely look up to linseed oil and measure some of my hormones.

Do you have any guess that why I’m quite opposite to other people at the changes of anxiousness? I had said that my anxiety got lower too while I’m worsening.

Kpavel, is there any possibility to that my problem based on ammonia levels? Could you look at the symptoms of the excess ammonia levels? Ammonia also indirectly stimulating the secretion allopregnanolone.

Ciprofloxacin wrote:I will definitely look up to linseed oil and measure some of my hormones.

Do you have any guess that why I’m quite opposite to other people at the changes of anxiousness? I had said that my anxiety got lower too while I’m worsening.

Something definitely changed in amygdala but guessing is difficult because anxiety like depression is attributed to myriads of causes. And they are interconnected if valid. I think depends on dose, time and man.

Ciprofloxacin wrote:Kpavel, is there any possibility to that my problem based on ammonia levels? Could you look at the symptoms of the excess ammonia levels? Ammonia also indirectly stimulating the secretion allopregnanolone.

As a consequence of inflammation.
May be like this
https://forums.phoenixrising.me/index.php?threads/blood-test-for-quinolinic-acid-neurotoxin-available.46841/
https://www.ncbi.nlm.nih.gov/pubmed/7694541

Yeah, I read. I think I need to get some help about the ammonia. Some says that its levels are not always shows up as high on tests. So, how can I diagnose if I really have hyperammonemia? I’m going to make a ammonia test anyway.

Ciprofloxacin wrote:Yeah, I read. I think I need to get some help about the ammonia. Some says that its levels are not always shows up as high on tests. So, how can I diagnose if I really have hyperammonemia? I’m going to make a ammonia test anyway.

Glutamine and Zinc can be used to reduce the ammonia level and relieve symptoms.

Glutamine Study --> https://www.ncbi.nlm.nih.gov/pubmed/18059593
Zinc Study --> https://www.ncbi.nlm.nih.gov/pubmed/1505922

Just found, may be interestin'
Effect of daily fiber intake on reproductive function: the BioCycle Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744625/
Relationship Between Caffeine Intake and Plasma Sex Hormone Concentrations in Premenopausal and Postmenopausal Women
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764240/