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Hey - almost a year update

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1Hey - almost a year update Empty Hey - almost a year update Thu Apr 18, 2019 10:25 am

weeniest



20 year old male. Iran (middle east) genetics. Chronic cannabis abuse from the age of 15. No previous SSRI or other drug use.

Symptoms:

Carbohydrate limitation and fasting helped with a lot of my old symptoms a lot. Some other symptoms were fixed by removing high dose of GABA-agent Valerian Root and losing fat from a bad bulk. GABA was elevated with Adrenaline in a low state (still is low/just enough to be relatively more asymptomatic)

If I had to label my personality, I would point to symptoms of schizoid/schizotypal personality disorder or a schizophrenic personality-type in general. Socially active, but difficulty when it comes to carrying conversations with females (no other social anxiety; no problem approaching women for the purpose for the purpose of their phone number)

cheek biting
loss of natural extroversion/color in life
no natural motivation just forced discipline
inner laziness/desire for passivity and escapism (youtube/netflix)
no libido/morningwood - occasional/rare spontaneous weak short-lived erections

(some mental traits may help)
realist/dreamer/big goals
intellectual - logic dominant, patient in life
above average musical ability

Experiments:

Proviron + YK-11 up to 100mg/day and 10mg/day: Slightest bit of drying and mental effect

(future) Mitochondria/Thyroid support



Last edited by weeniest on Sun Aug 16, 2020 9:35 am; edited 11 times in total

2Hey - almost a year update Empty Re: Hey - almost a year update Sun Feb 02, 2020 4:27 pm

weeniest



I need help interpreting a study. Does Cialis have any effect if any on cholesterol, improve or worsen? Was just curious for future reference.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433372/

For now I will take 350mg - 500mg Caffeine daily to help with Glutamate/Thyroid/Mitochondria dysfunction (not so coincidentally studies show THC downregulates glutamate long-term), and also the low blood pressure/adrenaline lowered by it too.

3Hey - almost a year update Empty Re: Hey - almost a year update Wed Feb 19, 2020 12:35 am

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight

Cannabis has a lot of active substances and much more targets than cb receptors, but cb1 is dangerous, I think and connecting it with lipids we can predict higher blood pressure and worsened baroreflex, not sure why you think it lowers it. See
https://www.ncbi.nlm.nih.gov/pubmed/29493561
Anandamide is harmful for sperm via TRPV1 for example.

4Hey - almost a year update Empty Re: Hey - almost a year update Sat Feb 29, 2020 4:49 pm

weeniest



kpavel wrote:Cannabis has a lot of active substances and much more targets than cb receptors, but cb1 is dangerous, I think and connecting it with lipids we can predict higher blood pressure and worsened baroreflex, not sure why you think it lowers it. See
https://www.ncbi.nlm.nih.gov/pubmed/29493561
Anandamide is harmful for sperm via TRPV1 for example.

It's actually funny you mention that,

One of the biggest breaks I had from Cannabis cold turkey had me have symptoms similar to below.

Before I started my bad bulk, I would sleep fine every night like normal.
Once I started my bad bulk, during the day I would feel hot, constipated, and would have bad bloating. I would also sweat at night and wake up sweating. Blood sugar levels and urinating habits out of whack too.

All high blood pressure symptoms and in relation with blood pressure.

However it seems that chronic-use lowers Noradrenaline, due to sensitization of Glutamate as one reason? (source available searching)

It is most likely there is other receptors that can be imbalanced through chronic deregulation to contribute to this.

This all comes to the conclusion: that Noradrenaline and BP do not have a complete strict linear connection. One can have high BP due to other hormonal imbalances, with Noradrenaline dysfunction within brain.

BP if you really think about it is your cardiovascular system as a complete separate entity. It's just the physical reflection for the exterior of ours bodies, in response to what is going on in the inside.

This would explain why stoners tend to be so relaxed, lazy, beta-like.

Was I bad bulking when not smoking Cannabis? I had a period of 150 days of Cannabis cessation. Even when I wasn't smoking I would have those symptoms. Cannabis just didn't seem to have any effect on BP. Cannabis in the end affects many different receptors, and Cannabis does have some homeostasis-like effects (Insulin, circadian rhythm, etc)

The study you provided shows CB1 through a high-fat diet. Though it is a good base, I wouldn't say high-BP was caused by Cannabis. Quite frankly - coincidentally more so the high-carb/high-fat/low-protein bad bulk. Insulin resistance raises BP, most likely one can say it was a combination of both Insulin and excess-CB1 activation.

That leads to another conclusion, that Cannabis does carry some homeostatic effects. At the same time, those lazy stoners won't most likely have high-BP being typically skinny people

I actually quit high-carb & high-fat because it helped a lot with the symptoms. Right now I'm on my 41 days of fasting, low-carb/high-protein/high-fat has me feeling the best I have in years. A big element of youthfulness added. I will just stick to 50g - 75g carbs a day for the rest of my life.

It seems as if high-fat diets even alone can cause excess CB1 receptor activation for me, but chronic smoking daily without high-fat diet doesn't even produce anything close to those symptoms I had. This is most likely due to the homeostatic elements of Cannabis, and also the many different terpenes that serve different agents within the brain to maintain homeostasis.

(okay fine, just because I've had this saved for years)
https://michaelvipperman.wordpress.com/2014/04/20/what-does-marijuana-do-it-rebalances-everything/

I did have it wrong that Cannabis was responsible for the majority of symptoms. But now I can't say I at this point have a good idea of what damage and to what extent I did do with it.

5Hey - almost a year update Empty Re: Hey - almost a year update Sun Mar 01, 2020 3:44 am

kpavel

kpavel
Area-1255 Intelligence Oversight
Area-1255 Intelligence Oversight

I looked through the arcticle, it's really good. Mentions smokers can have more visceral fat though, but I agree, old Jamaicans from reggae culture don't look obese. Anyway THC isn't https://en.wikipedia.org/wiki/Synthetic_cannabinoids#Toxicity
Same with hfd it can be very different. What I can DEFINITELY say arachidonic acid is evil. And it's source of complex network of endocannabinoids.
But we seek for how marijuana causes pleasure or interestingly can it help removing withdrawal from drugs like nicotine, cocaine, opioids? And what appetite increase feels like - just to relieve stress, wanting more fats, carbs or it's a taste for all food.

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