Austria wrote:Area,I hope I get it right, mianserin doesn't increase serotonin, it decreases it an pushes norepinephrin and dopamine....
Mianserin blocks multiple serotonin subtypes, that is correct, and it boosts dopamine and norepinephrine, but by different mechanisms. Mianserin essentially 'traps' the norepinephrine in synapse, leaving it active longer.
And when I look at wikipedia, it looks for me mianserin antagonises 5ht1a (1500 ki) also, is that right?
Then I could absolutely understand it's helping ability
Yes, but it is stronger as an antagonist at 5-HT2A/2C.
Would you generelly say mianserin increases sex drive?
I couldn't find much of experiences with mianserin...
It does, yes.
But with mirtazapin, which is only little different and there are many who say it decreases libido and some how get an increase in sex drive. Hmm
Mirtazapine is similar to mianserin, but lacks the NET inhibiting property, thus, it doesn't raise norepinephrine as much. Mirtazapine is hit or miss, it can boost sex drive for some users, others it decreases it. It does rapidly decrease cortisol, and is good for male bodybuilders.
Mirtazapine helps most, if it is combined with a 'true' 5-HT1A antagonist, and would be more valuable for PSSD sufferers, if there were 5-HT1A/1B antagonists available for us. http://www.ncbi.nlm.nih.gov/pubmed/11965359 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573454/
I somewhere read that with mianserin you only get raw dopamine and norepinephrine action and with mirtrazapin you get also serotonin action.
Can you may shed light on that please?
No, Mirtazapine isn't serotonergic necessarily, it just blocks some serotonin receptors, effectively 'redirecting' the serotonin already in one's system to the type 1 receptors. It may mildly* boost serotonin release in certain brain areas like the frontal cortex, by blocking alpha-2-autoreceptors which regulate both serotonin and norepinephrine, by blocking those receptors, the medication may boost both norepinephrine and serotonin release. http://www.ncbi.nlm.nih.gov/pubmed/9007838
So my questions are:
1. Is mianserin a 5ht1a antagonist? (even if only a little)
2. Does mianserin increase libido?
3. What is the difference between mianserin and mirtazapin, and what is the better choice for sex drive?
4. Can you get pssd from mianserin amd mirtazapin?
1.) A very weak one, yes.
2.) In some people, yes.
3.) Mianserin increases norepinephrine more than mirtazapine.
4.) No, but some people might not like the effects of them in general. They are good drugs though, some of the few that are actually safe and effective for depression and have positive effects on hormones as opposed to almost every other anti-depressant.
Area, I am very thankful for everything you do for pssd sufferers... can you give me your email-adress? I want to send you a voucher.
Thank you for the kind words. firstname.lastname@example.org