This information was originally written by area - 1255
I suggest EVERYONE WITH PSSD do the following.
1.) Check sex hormones, testosterone, estrogen, prolactin....progesterone , free testosterone, DHT {men}, DHEA.
**Check SHBG; sex hormone binding globulin**
2.) Check stress hormones; cortisol , ACTH (adreno corticotrophic hormone ), Adrenaline , noradrenaline.
3.) Comprehensive metabolic panel ; blood cells, oxygen status, thyroid hormones; TSH,T4,T3
If all of these check out , then you move to the next part which is re-booting some of the oxytcoinergic and dopaminergic pathways.
-TIANEPTINE / PITOLISANT combo will raise dopamine receptor expression.
-Naltrexone, amentoflavone or another opiate antagonist can be used to remove serotonin activity in the hypothalamus, and amplify dopamine and GABAergic activity. In this case expect testosterone to raise as well - and you should then monitor estrogen levels carefully.
YOU ARE MORE AT RISK FOR ESTROGEN CONVERSION IF YOU SMOKE OR ARE OVERWEIGHT.
-You should look into yohimbine combination with horny goat weed icariin 60% extract - and berberine is another great one.
-Berberine long-term use is recommended, because it downregulates pde-5's and is especially useful in combination with icariin.
-Berberine stops serotonin from vasoconstriction by 5-ht4 receptors
-Shilajit can be used to reduce serotonin levels, potentiate dopamine and acetylcholine and detoxify the body simultaneously.
-Vitex agnus castus extracts can deplete serotonin similar to tianeptine, and lower prolactin levels as well as modulate opiate/progesterone levels....high doses are not recommended, you only need a moderate dose.
-For short term or on demand fixes, a combination of cialis, yohimbine and an oxytocin injection may be of use. Masteron coupled with these or without the yohimbine but with the ciailis and oxytocin is another option.
-WAY 100,635 would be of use, but more than likely you would also need dual antagonism of multiple other serotonin subtypes..therefore way100,635 plus mianserin or cyproheptadine may be a great stack.
-Melatonin at night will antagonize 5-ht2a receptors.
-Raising histamine by means of l-histidine , folate and pitolisant may be of particular use in modulating central serotonergic activity.
-Alpha-1-blockers may improve erectile function but may not help or may worsen delayed ejaculation.
I suggest EVERYONE WITH PSSD do the following.
1.) Check sex hormones, testosterone, estrogen, prolactin....progesterone , free testosterone, DHT {men}, DHEA.
**Check SHBG; sex hormone binding globulin**
2.) Check stress hormones; cortisol , ACTH (adreno corticotrophic hormone ), Adrenaline , noradrenaline.
3.) Comprehensive metabolic panel ; blood cells, oxygen status, thyroid hormones; TSH,T4,T3
If all of these check out , then you move to the next part which is re-booting some of the oxytcoinergic and dopaminergic pathways.
-TIANEPTINE / PITOLISANT combo will raise dopamine receptor expression.
-Naltrexone, amentoflavone or another opiate antagonist can be used to remove serotonin activity in the hypothalamus, and amplify dopamine and GABAergic activity. In this case expect testosterone to raise as well - and you should then monitor estrogen levels carefully.
YOU ARE MORE AT RISK FOR ESTROGEN CONVERSION IF YOU SMOKE OR ARE OVERWEIGHT.
-You should look into yohimbine combination with horny goat weed icariin 60% extract - and berberine is another great one.
-Berberine long-term use is recommended, because it downregulates pde-5's and is especially useful in combination with icariin.
-Berberine stops serotonin from vasoconstriction by 5-ht4 receptors
-Shilajit can be used to reduce serotonin levels, potentiate dopamine and acetylcholine and detoxify the body simultaneously.
-Vitex agnus castus extracts can deplete serotonin similar to tianeptine, and lower prolactin levels as well as modulate opiate/progesterone levels....high doses are not recommended, you only need a moderate dose.
-For short term or on demand fixes, a combination of cialis, yohimbine and an oxytocin injection may be of use. Masteron coupled with these or without the yohimbine but with the ciailis and oxytocin is another option.
-WAY 100,635 would be of use, but more than likely you would also need dual antagonism of multiple other serotonin subtypes..therefore way100,635 plus mianserin or cyproheptadine may be a great stack.
-Melatonin at night will antagonize 5-ht2a receptors.
-Raising histamine by means of l-histidine , folate and pitolisant may be of particular use in modulating central serotonergic activity.
-Alpha-1-blockers may improve erectile function but may not help or may worsen delayed ejaculation.
