Jaxx wrote:Thanks ill look into that.
Any ideas on the combo Nortriptyline + Trintellix that is often mentioned at boards?
That combo would yield too much serotonin buildup. So no, not a good idea imHo. "California Rocket Fuel" which is Mirtazapine + Effexor is something that has sort of that premise behind it, but its far different as the former is primarily a serotonin antagonist, while Effexor is a stimulant norepinephrine-serotonin reuptake inhibitor. The combo yields norepinephrine activation because of the combined effects on norepinephrine systems compliment each other.
Nortriptylline + Trintellix would be all serotonin enhancement, even though Vortioxetine has serotonin antagonism, it still also has SERT-inhibiting properties, so on its own it is one thing, but with other SSRI's it is going to largely 'pro-serotonin'.
Therefore, Vortioxetine and Nortriptylline are a bad combo.