Got anhedonia and pssd, help please

Hello everyone, I am new here, my name is johns.
Two years ago, I got anhedonia and pssd because of depression and ssri. The most difficult depression has passed, but I still live a life of death. This is a completely different experience.
I can't be interested in anything. I can smell the smell of food and taste their taste, but I don't have a mood, I don't have the desire to enjoy food.I don't watch movies anymore, I don't listen to music anymore, and the music that makes me very happy in memory is just noise for me.

When I started taking zoloft because of anxiety two years ago, I noticed that my sense of happiness and libido began to drop sharply. I started to be depressed. I quickly stopped taking it. After a few months, my condition was finally bad enough to take Prozac and low-dose olanzapine, which was given to me by my psychiatrist. During the medication, I finally became the current anhedonia, and my genitals became numb, I couldn’t feel the climax, and ejaculation was like peeing.
After stopping taking it, although my genitals feel numb, I can erect and ejaculate, but anhedonia does not relieve.
Later I tried duloxetine, then a combination of brintellix and low-dose aripiprazole, and damn they didn't work.

I also have a very strong brain fog, just like dreaming. I have taken sarcosine in the past few weeks. It helps me to get rid of the strong feeling of powerlessness. I am taking 1.5 grams a day.With a little cola or coffee, I can keep my spirit all day long.

I finally found this forum, Area looks very professional,
I don't know how long I can hold on, anhedonia and pssd basically kill me, I watch porn movies can erect, but my penis doesn't feel a bit, my heart doesn't feel a bit too, I can force myself to climax, I ejaculate I feel physical tension, but I am not a little happy.
I hope someone can help me. I hope someone can tell me what supplements or drugs I should take. I don't have any pharmacological knowledge.
If anyone can suggest what I should take, I would be grateful.
I will record the changes in my symptoms and the effect of taking the medicine in this forum.
Whether I can succeed or not, this is a reference for others.

Anyone please， help me, give me a message, tell me that some of you are there, give me some confidence, please.

Hello johns, I'm kpavel, the Ghost of this forum, lol. Area-1255/Jay is usually busy with research and communication. Also if you want big community get to pssdforum and everyone's there including me, guarantee that, only who will answer depends. I'm doing a lot of research too and know current situation and trends more or less. I also have my own ideas, plenty of material to experiment, some different from any current ones. You know, situation was let's try inositol or Saint John's Wort just a few years ago, but now I feel much more opportunities, guys are more active, not everyone but many. We are not in seventies-nineties, that time was practically medievil for a condition like pssd. I'm Russian by the way, and you? You can write to PM if you wish, simply interesting, how you found us.

kpavel wrote:Hello johns, I'm kpavel, the Ghost of this forum, lol. Area-1255/Jay is usually busy with research and communication. Also if you want big community get to pssdforum and everyone's there including me, guarantee that, only who will answer depends. I'm doing a lot of research too and know current situation and trends more or less. I also have my own ideas, plenty of material to experiment, some different from any current ones. You know, situation was let's try inositol or Saint John's Wort just a few years ago, but now I feel much more opportunities, guys are more active, not everyone but many. We are not in seventies-nineties, that time was practically medievil  for a condition like pssd. I'm Russian by the way, and you? You can write to PM if you wish, simply interesting, how you found us.

Hello, kpavel, I feel very surprised when I see you replying to me.  I almost have no hope of getting a reply, because I browsed other posts, no intention to offend, although the quality of the posts here is very high, but there seems to be no activity，
I am from Hong Kong, China. I am very happy to meet friends from different countries. My English is not very good. I don't know much about your culture. If there is anything wrong with what I said, I would apologize.
I just came over from the frustration and bitterness that can lead to suicide a few days ago. Now I am going to try something new. I realize that no one can give me the answer directly, but can only give me advice.
Everyone is different, I have to adjust according to my own experience, yes, now I am not so desperate.
I saw an answer from the Quora, about anhedonia, the respondent provided us with a link to guide me to this forum. I have also been to pssdforum, which seems to be full of ideas and research. I just got involved in this field. I don't know pharmacology, and I haven't read a few papers. Everything there makes me confused.
You seem to have been in this forum for a long time, kpavel, you must be very experienced, can you tell me how to start my experiment? Now my biggest concern is the interaction of drugs. Can you teach me how to avoid it?
I also don't know which drugs to start with. I decided to keep sarcosine. Can you recommend some hopeful ones?
Finally, I really appreciate that you can help me, I will pm when I am confused, when do you not want to be disturbed?

Today I tried nac again. There are many people on reddit who take it and sarcosine as a combination. The brand called profrontal is also a combination of them. They are mainly used to treat anhedonia.
Many people on reddit say that nac has an effect on anxiety, ocd and sct. I used to see blogs about low activation and obsessive-compulsive disorder in our forum.
So I am going to give it a try.
I took 500mg of nac at 8 o'clock in the morning. I felt that my brainfog was obviously improved. I felt more energetic, but I feltI feel numb at the same time. I touched my skin and nipples, no longer feeling so comfortable, a little numb,
In the afternoon, I took their combination. I waited for an hour and started masturbating. I noticed that my genitals became more numb, and the pleasure of the climax was further reduced.  I  still shot a lot of sperm just like before, .
So I only took sarcosine at night, it brought me benefits and made me look back.
I don't understand pharmacology. What I feel is the benefit of nac in activating the spirit, but it also worsens my physical and psychological sensation.
In fact, I also tried to take a combination for three weeks before. At that time, it was the same feeling as now. It is better to take nac alone than to take a combination.
It took two hours to take effect and it lasted for a week. I am so sensitive to any medicine, and it has always been.
I will use nac as a safer Ritalin in the future. After all, I only feel its benefits for sct.

johns wrote:

kpavel wrote:Hello johns, I'm kpavel, the Ghost of this forum, lol. Area-1255/Jay is usually busy with research and communication. Also if you want big community get to pssdforum and everyone's there including me, guarantee that, only who will answer depends. I'm doing a lot of research too and know current situation and trends more or less. I also have my own ideas, plenty of material to experiment, some different from any current ones. You know, situation was let's try inositol or Saint John's Wort just a few years ago, but now I feel much more opportunities, guys are more active, not everyone but many. We are not in seventies-nineties, that time was practically medievil  for a condition like pssd. I'm Russian by the way, and you? You can write to PM if you wish, simply interesting, how you found us.

Hello, kpavel, I feel very surprised when I see you replying to me.  I almost have no hope of getting a reply, because I browsed other posts, no intention to offend, although the quality of the posts here is very high, but there seems to be no activity，
I am from Hong Kong, China. I am very happy to meet friends from different countries. My English is not very good. I don't know much about your culture. If there is anything wrong with what I said, I would apologize.
I just came over from the frustration and bitterness that can lead to suicide a few days ago. Now I am going to try something new. I realize that no one can give me the answer directly, but can only give me advice.
Everyone is different, I have to adjust according to my own experience, yes, now I am not so desperate.
I saw an answer from the Quora, about anhedonia, the respondent provided us with a link to guide me to this forum. I have also been to pssdforum, which seems to be full of ideas and research. I just got involved in this field. I don't know pharmacology, and I haven't read a few papers. Everything there makes me confused.
You seem to have been in this forum for a long time, kpavel, you must be very experienced, can you tell me how to start my experiment? Now my biggest concern is the interaction of drugs. Can you teach me how to avoid it?
I also don't know which drugs to start with. I decided to keep sarcosine. Can you recommend some hopeful ones?
Finally, I really appreciate that you can help me, I will pm when I am confused, when do you not want to be disturbed?

Understood. I am not from English culture actually, we have our own traditions that suffered quite a bit in the last century. But yes, Russians still belong to Western culture. I watched some historical videos about China, how ancient Romans visited it, how great Zhèng Hé opened world to Chinese, about Empress and a centurry of uprisings and catastrophe that led to Deng Xiaoping building a modern country.

johns wrote:Today I tried nac again. There are many people on reddit who take it and sarcosine as a combination. The brand called profrontal is also a combination of them. They are mainly used to treat anhedonia.
Many people on reddit say that nac has an effect on anxiety, ocd and sct. I used to see blogs about low activation and obsessive-compulsive disorder in our forum.
So I am going to give it a try.
I took 500mg of nac at 8 o'clock in the morning. I felt that my brainfog was obviously improved. I felt more energetic, but I feltI feel numb at the same time. I touched my skin and nipples, no longer feeling so comfortable, a little numb,
In the afternoon, I took their combination. I waited for an hour and started masturbating. I noticed that my genitals became more numb, and the pleasure of the climax was further reduced.  I  still shot a lot of sperm just like before, .
So I only took sarcosine at night, it brought me benefits and made me look back.
I don't understand pharmacology. What I feel is the benefit of nac in activating the spirit, but it also worsens my physical and psychological sensation.
In fact, I also tried to take a combination for three weeks before. At that time, it was the same feeling as now. It is better to take nac alone than to take a combination.
It took two hours to take effect and it lasted for a week. I am so sensitive to any medicine, and it has always been.
I will use nac as a safer Ritalin in the future. After all, I only feel its benefits for sct.

Interesting, n-acetylcysteine helps raise glutathione so no surprise it helps with oxidative stress and this relieves brain fog in general sense but not sure how to compare it to amphetamines which have completely different mechanisms of action but really can help anhedonia for a short time. You feel numbness ONLY from combination with sarcosine or from NAC alone? NAC is also a medication to take against paracetamol's liver toxicity. Some time ago people reported numbness or even crash in erectile capability and cognition with paracetamol use. So logically this all looks contradictive.
I guess sarcosine helps you doing things that are more complex than watching TV or playing, right? Does it also change sensitivity when take alone without caffeine? Also are you prone to anxiety, irritability?

Also you know herbs can be mixed in formulas for more effect. It's better not to mix drugs so let's test synthetic drugs one by one very cautiously.

kpavel wrote:

johns wrote:Today I tried nac again. There are many people on reddit who take it and sarcosine as a combination. The brand called profrontal is also a combination of them. They are mainly used to treat anhedonia.
Many people on reddit say that nac has an effect on anxiety, ocd and sct. I used to see blogs about low activation and obsessive-compulsive disorder in our forum.
So I am going to give it a try.
I took 500mg of nac at 8 o'clock in the morning. I felt that my brainfog was obviously improved. I felt more energetic, but I feltI feel numb at the same time. I touched my skin and nipples, no longer feeling so comfortable, a little numb,
In the afternoon, I took their combination. I waited for an hour and started masturbating. I noticed that my genitals became more numb, and the pleasure of the climax was further reduced.  I  still shot a lot of sperm just like before, .
So I only took sarcosine at night, it brought me benefits and made me look back.
I don't understand pharmacology. What I feel is the benefit of nac in activating the spirit, but it also worsens my physical and psychological sensation.
In fact, I also tried to take a combination for three weeks before. At that time, it was the same feeling as now. It is better to take nac alone than to take a combination.
It took two hours to take effect and it lasted for a week. I am so sensitive to any medicine, and it has always been.
I will use nac as a safer Ritalin in the future. After all, I only feel its benefits for sct.

Interesting, n-acetylcysteine helps raise glutathione so no surprise it helps with oxidative stress and this relieves brain fog in general sense but not sure how to compare it to amphetamines which have completely different mechanisms of action but really can help anhedonia for a short time. You feel numbness ONLY from combination with sarcosine or from NAC alone? NAC is also a medication to take against paracetamol's liver toxicity. Some time ago people reported numbness or even crash in erectile capability and cognition with paracetamol use. So logically this all looks contradictive.
I guess sarcosine helps you doing things that are more complex than watching TV or playing, right? Does it also change sensitivity when take alone without caffeine? Also are you prone to anxiety, irritability?

Yes, kpavel, I did feel calm and numb after using nac, whether it was taken alone or combined with sarcosine,
I also looked up the content of acetaminophen. I didn't even know what it was before you mentioned it. Hahaha, nac causes numbness and it can be used to treat the hepatotoxicity of acetaminophen. It seems to be very contradictory. It is also the reason why I am so confused in various news and theories. After reviewing so many theories, I have never been able to connect them with practice. This is why I trust people in this forum so much. You are very knowledgeable and have experience,
Perhaps for me, experimenting with drugs, observing and recording my feelings is the way to solve problems.
Nac does allow me to get rid of sct to a certain extent, which makes it easier for me to work. Yes, it performs well in this respect. It is better than Ritalin or Tomoxetine. They don't even work.
At present, it seems that I can feel a little more happy only when I take caffeinated food. I don’t feel any sense at all other times, even sadness and frustration are not obvious.
Now that I don't feel anxious often, I have been working with a psychoanalyst and have been sticking to it for a long time. It has helped me a lot. In fact, it works better than cbt, but it takes a lot of time. Energy and money, I have recovered very well now, except for my anhedonia and pssd, which is quite tormenting me.

kpavel wrote:Also you know herbs can be mixed in formulas for more effect. It's better not to mix drugs so let's test synthetic drugs one by one very cautiously.

Thank you kpavel , but I have some questions,
Does herbal medicine mean natural medicine? Is the shilajit mentioned in the forum an herbal medicine? Are synthetic drugs a few new compounds, such as some psychiatric drugs? Is sjw and sam-e synthetic drugs?
Are herbs safer than synthetic drugs? If I use herbs, can I take them all at once, even if they have several? I have never tried to take more than two combinations of drugs at the same time.
And what herbs do you think might help me?

Herbs are from Nature. Shilajit seems to be an unique dead plant thick black substance found in mountains north to India. But synthetic drugs made in laboratory, not found in nature. First drugs were made in XIX century from coal tar for example. Some drugs remind natural stuff but they are simplified and changed to be patented and sold for any price wished. The art of laboratories still isn't perfect that's why so many bad effects. But there are a lot of natural poisons of course.
SJW is a popular herb, SAMe is an endogenous molecule, human body is a big lab.

From herbs you may try Ginkgo Biloba tea or good extract capsules ~60-240 mg for 2-4 weeks. It helped many, temporarily though. Some reported side effects or nothing.

By the way shilajit may be helpful too, some people reported sexual benefits from it.

kpavel wrote:Herbs are from Nature. Shilajit seems to be an unique dead plant thick black substance found in mountains north to India. But synthetic drugs made in laboratory, not found in nature. First drugs were made in XIX century from coal tar for example. Some drugs remind natural stuff but they are simplified and changed to be patented and sold for any price wished. The art of laboratories still isn't perfect that's why so many bad effects. But there are a lot of natural poisons of course.
SJW is a popular herb, SAMe is an endogenous molecule, human body is a big lab.

From herbs you may try Ginkgo Biloba tea or good extract capsules ~60-240 mg for 2-4 weeks. It helped many, temporarily though. Some reported side effects or nothing.

Thank you for your advice, kpavel, you are so kind, I will include it in my plan, and after a while I will return to the forum to record my progress.