My History

phenyl90 wrote:I was thinking of inserting something before I slept, I can easily fall asleep but I always wake up in the middle of the night to go to the bathroom and in the morning I always have an early awakening.

phenyl90 wrote:Ok thanks,

and about my other question?

phenyl90 wrote:I repeat the exam in another Lab for two time and level of Copper is normal/low and Serotonin is normal.

So i think now, my focus is to Up histamine with Hisitine, Zinc, B12, B3, Folic acid and with Antagonist H3. (At the moment not have but i find good source of Kutaj from Morpheme, is legit ? ).

I use 30mg Zinc, Folic acid from Now Food 800mg, B12 1000mg, B3 500mg and histidine 500mg before meal. Totally is 1500-2gr daily.

Regarding my old blood exam i have noted that the levels of basophil, neutrophils and the other white blood cells they have always been low.

Is this a sign of low production of histamine? and probably an oversimplification? even if my serotonin appears as normal and my dopamine is certainly not at high levels.

I have find this image very explanatory:

https://imgur.com/a/JpZkf

I'm pretty confused about how to manage the diet at this point, probably the "Peat" style and the foods he gives / banished are not really ideal for me. I have more desire for food during the day (sign of Dopamine low and general catecolamine not high).

What do you think about it?

Thanks guys, it's always nice to read and have a big help from you.

kpavel wrote:

phenyl90 wrote:Ok thanks,

and about my other question?

In basic blood counts I had low neutrophisl and lymphocytes too. Basophils were higher. Can you post your test in numbers to compare (for red and white cells)?

About diet I didn't understand but Mediterranean traditional diet is good. Some fish and meat (stew, steam, boil), eggs, some milk, vegs, legumes, fruits and berries, a little grain, a little butter and no processed foods is fine from many points of view.

phenyl90 wrote:

phenyl90 wrote:I repeat the exam in another Lab for two time and level of Copper is normal/low and Serotonin is normal.

So i think now, my focus is to Up histamine with Hisitine, Zinc, B12, B3, Folic acid and with Antagonist H3. (At the moment not have but i find good source of Kutaj from Morpheme, is legit ? ).

I use 30mg Zinc, Folic acid from Now Food 800mg, B12 1000mg, B3 500mg and histidine 500mg before meal. Totally is 1500-2gr daily.

Regarding my old blood exam i have noted that the levels of basophil, neutrophils and the other white blood cells they have always been low.

Is this a sign of low production of histamine? and probably an oversimplification? even if my serotonin appears as normal and my dopamine is certainly not at high levels.

I have find this image very explanatory:

https://imgur.com/a/JpZkf

I'm pretty confused about how to manage the diet at this point, probably the "Peat" style and the foods he gives / banished are not really ideal for me. I have more desire for food during the day (sign of Dopamine low and general catecolamine not high).

What do you think about it?

Thanks guys, it's always nice to read and have a big help from you.

What do you think  Area ?

I think my low histamine is not related to a high copper level because the analyzes give me a normal result.

Therefore I also think that my methylation is normal but surely having used SSRI in the past my serotonin has remained high and certainly dopamine is low.

Do you always suggest to use BCAA and Tyrosine after meals? because I start using several supplements and I would like to avoid interactions.

Thank you

kpavel wrote:Memantine could be an interesting drug, but not sure it will be without serious sides. May touch memory or vision. Zinc or Mg or Mn are NMDA antagonists too.

phenyl90 wrote:

kpavel wrote:Memantine could be an interesting drug, but not sure it will be without serious sides. May touch memory or vision. Zinc or Mg or Mn are NMDA antagonists too.

Understood, other NMDA antagonists are aspartic acid and glycine that is contained in gelatin, correct?

I would like to somehow act on the 5-HTP1A serotonin receptor which I think I have very high levels. This provokes me above all anticipatory anxiety.


https://imgur.com/a/RDy6h8u

kpavel wrote:

phenyl90 wrote:

kpavel wrote:Memantine could be an interesting drug, but not sure it will be without serious sides. May touch memory or vision. Zinc or Mg or Mn are NMDA antagonists too.

Understood, other NMDA antagonists are aspartic acid and glycine that is contained in gelatin, correct?

I would like to somehow act on the 5-HTP1A serotonin receptor which I think I have very high levels. This provokes me above all anticipatory anxiety.


https://imgur.com/a/RDy6h8u

No, glycine and daa are positive modulators.

By anticipatory anxiety you mean tension and doubt?
You may try milk thistle for a month, it could help this theoretically.
And it interacts with 5ht1a in a way opposite to the receptor's classic agonist. Not sure how this will treat depression.
https://www.ncbi.nlm.nih.gov/pubmed/29175455
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276319/
https://link.springer.com/article/10.1007%2Fs11062-012-9266-0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813094/

By the way I'm trying it from Tuesday, so can compare.

Area-1255 wrote:

phenyl90 wrote:

phenyl90 wrote:I repeat the exam in another Lab for two time and level of Copper is normal/low and Serotonin is normal.

So i think now, my focus is to Up histamine with Hisitine, Zinc, B12, B3, Folic acid and with Antagonist H3. (At the moment not have but i find good source of Kutaj from Morpheme, is legit ? ).

I use 30mg Zinc, Folic acid from Now Food 800mg, B12 1000mg, B3 500mg and histidine 500mg before meal. Totally is 1500-2gr daily.

Regarding my old blood exam i have noted that the levels of basophil, neutrophils and the other white blood cells they have always been low.

Is this a sign of low production of histamine? and probably an oversimplification? even if my serotonin appears as normal and my dopamine is certainly not at high levels.

I have find this image very explanatory:

https://imgur.com/a/JpZkf

I'm pretty confused about how to manage the diet at this point, probably the "Peat" style and the foods he gives / banished are not really ideal for me. I have more desire for food during the day (sign of Dopamine low and general catecolamine not high).

What do you think about it?

Thanks guys, it's always nice to read and have a big help from you.

What do you think  Area ?

I think my low histamine is not related to a high copper level because the analyzes give me a normal result.

Therefore I also think that my methylation is normal but surely having used SSRI in the past my serotonin has remained high and certainly dopamine is low.

Do you always suggest to use BCAA and Tyrosine after meals? because I start using several supplements and I would like to avoid interactions.

Thank you

Yes, Morpheme Kutaj/Connesi Bark is legit. You can combine with Yamoa, a patented Funtumia Elastica extract for maximal effect/H3-inhibition.

...But some folks find using BOTH to be TOO stimulating.

They definitely should solve a number of issues though including...
--> Low Histamine
--> Low Acetylcholine
--> Low Adrenaline
---> Low Dopamine.

...Then also use the BCAA + L-Tyrosine as we discussed...and continue with L-Histidine.

phenyl90 wrote:

kpavel wrote:

phenyl90 wrote:

kpavel wrote:Memantine could be an interesting drug, but not sure it will be without serious sides. May touch memory or vision. Zinc or Mg or Mn are NMDA antagonists too.

Understood, other NMDA antagonists are aspartic acid and glycine that is contained in gelatin, correct?

I would like to somehow act on the 5-HTP1A serotonin receptor which I think I have very high levels. This provokes me above all anticipatory anxiety.


https://imgur.com/a/RDy6h8u

No, glycine and daa are positive modulators.

By anticipatory anxiety you mean tension and doubt?
You may try milk thistle for a month, it could help this theoretically.
And it interacts with 5ht1a in a way opposite to the receptor's classic agonist. Not sure how this will treat depression.
https://www.ncbi.nlm.nih.gov/pubmed/29175455
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276319/
https://link.springer.com/article/10.1007%2Fs11062-012-9266-0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813094/

By the way I'm trying it from Tuesday, so can compare.

Anticipatory anxiety as described in the image that I attached above (see?), Paranoia (but I think for high serotonin in general so I can not skew on which receptor, but most likely 5-HTP1A), and always that odious feeling that people me be watching and thinking about what I'm thinking.

I hope that in the time selegiline help me to raise dopamine and at least solve the symptoms of ADHD ... and consequently also to balance the serotonin.

I'll try the milk thistle then, but on the glycine you mean that things get worse on that receptor?

phenyl90 wrote:Niacinamide lower serotonin and up dopamine ? because i read niacinamide lower dopamine.

kpavel wrote:I think knowing your homocysteine and folic acid levels will make more on decision. Probably testing for mthfr deficiency.
And which studies do you mean? I think you don't want high intestinal serotonin too.

https://www.ncbi.nlm.nih.gov/pubmed/18950248
https://www.ncbi.nlm.nih.gov/pubmed/28477545
https://www.ncbi.nlm.nih.gov/pubmed/25228807
Many controversive things.

phenyl90 wrote:

kpavel wrote:I think knowing your homocysteine and folic acid levels will make more on decision. Probably testing for mthfr deficiency.
And which studies do you mean? I think you don't want high intestinal serotonin too.

https://www.ncbi.nlm.nih.gov/pubmed/18950248
https://www.ncbi.nlm.nih.gov/pubmed/28477545
https://www.ncbi.nlm.nih.gov/pubmed/25228807
Many controversive things.

absolutely, but I see that it does not have much to do with the intestinal as in my case because if I eat all foods with high tryptophan I do not have any symptoms related to high serotonin.

Consider that the first signs were 14 years during football games where sounds and sudden noises bothered me ... obviously the anticipatory anxiety that had already risen the day before. That said I think that in my case the brain part, which is in the minority if I'm not mistaken only 10%, is the master.

So you say that folic acid can stop it? at most I take histidine ... and I already consume a lot of aged cheese.

kpavel wrote:

phenyl90 wrote:

kpavel wrote:I think knowing your homocysteine and folic acid levels will make more on decision. Probably testing for mthfr deficiency.
And which studies do you mean? I think you don't want high intestinal serotonin too.

https://www.ncbi.nlm.nih.gov/pubmed/18950248
https://www.ncbi.nlm.nih.gov/pubmed/28477545
https://www.ncbi.nlm.nih.gov/pubmed/25228807
Many controversive things.

absolutely, but I see that it does not have much to do with the intestinal as in my case because if I eat all foods with high tryptophan I do not have any symptoms related to high serotonin.

Consider that the first signs were 14 years during football games where sounds and sudden noises bothered me ... obviously the anticipatory anxiety that had already risen the day before. That said I think that in my case the brain part, which is in the minority if I'm not mistaken only 10%, is the master.

So you say that folic acid can stop it? at most I take histidine ... and I already consume a lot of aged cheese.

No, I wanted to say that I don't know how folic acid will act. If you for example have high homocysteine and normal folic acid this may mean you have a deficiency in methylfolate. And excess folic acid may create problems instead of solving them. Also mothers were long time ago offered to take folic acid in pregnancy.
Infection like streptococcus can play a role in anxiety.

phenyl90 wrote:Is it possible to take kutaj and syrian rue together with selegiline ?

phenyl90 wrote:

kpavel wrote:

phenyl90 wrote:

kpavel wrote:I think knowing your homocysteine and folic acid levels will make more on decision. Probably testing for mthfr deficiency.
And which studies do you mean? I think you don't want high intestinal serotonin too.

https://www.ncbi.nlm.nih.gov/pubmed/18950248
https://www.ncbi.nlm.nih.gov/pubmed/28477545
https://www.ncbi.nlm.nih.gov/pubmed/25228807
Many controversive things.

absolutely, but I see that it does not have much to do with the intestinal as in my case because if I eat all foods with high tryptophan I do not have any symptoms related to high serotonin.

Consider that the first signs were 14 years during football games where sounds and sudden noises bothered me ... obviously the anticipatory anxiety that had already risen the day before. That said I think that in my case the brain part, which is in the minority if I'm not mistaken only 10%, is the master.

So you say that folic acid can stop it? at most I take histidine ... and I already consume a lot of aged cheese.

No, I wanted to say that I don't know how folic acid will act. If you for example have high homocysteine and normal folic acid this may mean you have a deficiency in methylfolate. And excess folic acid may create problems instead of solving them. Also mothers were long time ago offered to take folic acid in pregnancy.
Infection like streptococcus can play a role in anxiety.

then tomorrow I will do the homocysteine and folic acid analyzes but I would not want them to be distorted because I took folic acid for about a month for histamine. Advice to wait before doing blood tests? Other parameters that I could evaluate? considers that histamine can not be analyzed.

The thing that I really care about is not having false positives or negatives in the result of the exams.